Blog ideas

Topics

• Organic food and the issue of sticking to a hypothesis even after its founding principles have been taking away.
• "Operons", antisense gene pairs and other unusual transcriptional units in eukaryotes (e.g. Lipovich's papers) -- keep for L+H?
• The problems that you need to overcome in industrial GM -- e.g. codon usage bias variation between species, differences in available post-translational modification, targeted insertion,,,

Themes/series

• Tumour adaptations -- e.g. immune evasion, angiogenesis, chemo resistance, invasion, metastasis
• How drugs work -- molecular targets, metabolic and signalling pathways, etc.
• Useful things we wouldn't know if it weren't for genome projects

Papers

Rzhetsky A, Zheng T, Weinreb C. Self-correcting maps of molecular pathways. PLoS ONE. 2006 Dec 20;1:e61. PMID: 1718369

Penny, D., Phillips, M.J. The rise of birds and mammals: Are microevolutionary processes sufficient for macroevolution? (2004) Trends in Ecology and Evolution, 19 (10), pp. 516-522. Cited 14 times. http://www.scopus.com/scopus/inward/record.url?eid=2-s2.0-4544292696&partnerID=40&rel=R7.0.0 DOI: 10.1016/j.tree.2004.07.015

Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R, Clark AG, Bustamante CD. Proportionally more deleterious genetic variation in European than in African populations. Nature. 2008 Feb 21;451(7181):994-7. PMID: 18288194